Summary The aim of this study is to investigate the needs of carers’ of EOD patients, roles of Nurses, particularly detailing roles they could play in order to alleviate some of the challenges that carers’ of EOD patient face in today’s society. Problems posed to be answered for this study were; what are the needs and challenges of EOD Spouses? And, how can Nurses help to mitigate these challenges? Travelbee’s theory of human-to-human relationship was used as the framework for the study. This study was conducted with qualitative method and data was collected through literature review. 11 articles were finally selected and analyzed using The Matrix. Three main categories emerged from the analysis; psychological burden, emotional burden and socio-economic burden. The results reflect on the challenges of spouses of EOD patients are faced with as their loved ones face the diagnosis of early onset dementia. There are several unmet needs from the perspective of spouses such as; informational, professional support etc. Moreover, spouses expressed how assuming the sudden role as caregiver to their loved ones brought a barrier between the companionship they once enjoyed.