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Abstract Nonlocal image representation has been successfully used in many image-related inverse problems including denoising, deblurring and deblocking. However, most existing methods only consider the nonlocal self-similarity (NSS) prior of degraded observation image, and few methods use the NSS prior from natural images. In this paper we propose a novel method for image denoising via group sparsity residual constraint with external NSS prior (GSRC-ENSS). Different from the previous NSS prior-based denoising methods, two kinds of NSS prior (e.g., NSS priors of noisy image and natural images) are used for image denoising. In particular, to enhance the performance of image denoising, the group sparsity residual is proposed, and thus the problem of image denoising is translated into reducing the group sparsity residual. Because the groups contain a large amount of NSS information of natural images, to reduce the group sparsity residual, we obtain a good estimation of the group sparse coefficients of the original image by the external NSS prior based on Gaussian Mixture Model (GMM) learning, and the group sparse coefficients of noisy image are used to approximate the estimation. To combine these two NSS priors better, an effective iterative shrinkage algorithm is developed to solve the proposed GSRC-ENSS model. Experimental results demonstrate that the proposed GSRC-ENSS not only outperforms several state-of-the-art methods, but also delivers the best qualitative denoising results with finer details and less ringing artifacts.
Abstract Compressed sensing (CS) has been successfully utilized by many computer vision applications. However,the task of signal reconstruction is still challenging, especially when we only have the CS measurements of an image (CS image reconstruction). Compared with the task of traditional image restoration (e.g., image denosing, debluring and inpainting, etc.), CS image reconstruction has partly structure or local features. It is difficult to build a dictionary for CS image reconstruction from itself. Few studies have shown promising reconstruction performance since most of the existing methods employed a fixed set of bases (e.g., wavelets, DCT, and gradient spaces) as the dictionary, which lack the adaptivity to fit image local structures. In this paper, we propose an adaptive sparse nonlocal regularization (ASNR) approach for CS image reconstruction. In ASNR, an effective self-adaptive learning dictionary is used to greatly reduce artifacts and the loss of fine details. The dictionary is compact and learned from the reconstructed image itself rather than natural image dataset. Furthermore, the image sparse nonlocal (or nonlocal self-similarity) priors are integrated into the regularization term, thus ASNR can effectively enhance the quality of the CS image reconstruction. To improve the computational efficiency of the ASNR, the split Bregman iteration based technique is also developed, which can exhibit better convergence performance than iterative shrinkage/thresholding method. Extensive experimental results demonstrate that the proposed ASNR method can effectively reconstruct fine structures and suppress visual artifacts, outperforming state-of-the-art performance in terms of both the PSNR and visual measurements.
Abstract Objective: To conduct a comprehensive analysis of circulating metabolites and incident stroke in large prospective population-based settings. Methods: We investigated the association of metabolites with risk of stroke in 7 prospective cohort studies including 1,791 incident stroke events among 38,797 participants in whom circulating metabolites were measured by nuclear magnetic resonance technology. The relationship between metabolites and stroke was assessed with Cox proportional hazards regression models. The analyses were performed considering all incident stroke events and ischemic and hemorrhagic events separately. Results: The analyses revealed 10 significant metabolite associations. Amino acid histidine (hazard ratio [HR] per SD 0.90, 95% confidence interval [CI] 0.85, 0.94; p = 4.45 × 10−5), glycolysis-related metabolite pyruvate (HR per SD 1.09, 95% CI 1.04, 1.14; p = 7.45 × 10−4), acute-phase reaction marker glycoprotein acetyls (HR per SD 1.09, 95% CI 1.03, 1.15; p = 1.27 × 10−3), cholesterol in high-density lipoprotein (HDL) 2, and several other lipoprotein particles were associated with risk of stroke. When focused on incident ischemic stroke, a significant association was observed with phenylalanine (HR per SD 1.12, 95% CI 1.05, 1.19; p = 4.13 × 10−4) and total and free cholesterol in large HDL particles. Conclusions: We found association of amino acids, glycolysis-related metabolites, acute-phase reaction markers, and several lipoprotein subfractions with the risk of stroke. These findings support the potential of metabolomics to provide new insights into the metabolic changes preceding stroke.
Reduced glomerular filtration rate (GFR) can progress to kidney failure. Risk factors include genetics and diabetes mellitus (DM), but little is known about their interaction. We conducted genome-wide association meta-analyses for estimated GFR based on serum creatinine (eGFR), separately for individuals with or without DM (nDM = 178,691, nnoDM = 1,296,113). Our genome-wide searches identified (i) seven eGFR loci with significant DM/noDM-difference, (ii) four additional novel loci with suggestive difference and (iii) 28 further novel loci (including CUBN) by allowing for potential difference. GWAS on eGFR among DM individuals identified 2 known and 27 potentially responsible loci for diabetic kidney disease. Gene prioritization highlighted 18 genes that may inform reno-protective drug development. We highlight the existence of DM-only and noDM-only effects, which can inform about the target group, if respective genes are advanced as drug targets. Largely shared effects suggest that most drug interventions to alter eGFR should be effective in DM and noDM.