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The feasibility of aerobic vessel composting and anaerobic digestion for the treatment of pulp and paper mill sludges were studied. The composting studies made use of primary and secondary sludge from a de-inking and paper mill. In six parallely aerated 500 1 vessels with various carbon : nitrogen (C:N) -ratios, the most optimal performance was obtained with C:N -ratios of c. 22–35, while higher and lower ratios delayed the temperature increase. With the optimal ratios, the thermophilic stage was reached within 36 h, and the stage lasted for about seven days. In the scale-up study (18 m3 compost vessel), the thermophilic stage was reached within 24 h. An effective dehydratation of the mass was obtained as the total solids (TS) content of the compost increased from 31.3– to 63.8– within 21 days. The anaerobic digestion of pulp and paper mill sludges was studied using two mesophilic 5 1 digesters, their feed sludges consisting of a mixture of municipal sewage sludge and primary and secondary sludge from a pulp and paper mill. With this feed mixture and with a loading rate of about 1.0 kg volatile solids (VS)/m3d a removal of about 27 to 40– VS and methane production of about 180 1/kgVSadded feed sludge were achieved during the 80 d study period. The study showed that pulp and paper mill sludges are amenable to both aerobic composting and anaerobic digestion.
Circulating metabolites systemically reflect cellular processes and can modulate the tissue microenvironment in complex ways, potentially impacting cancer initiation processes. Genetic background increases cancer risk in individuals with Lynch syndrome; however, not all carriers develop cancer. Various lifestyle factors can influence Lynch syndrome cancer risk, and lifestyle choices actively shape systemic metabolism, with circulating metabolites potentially serving as the mechanical link between lifestyle and cancer risk. This study aims to characterize the circulating metabolome of Lynch syndrome carriers, shedding light on the energy metabolism status in this cancer predisposition syndrome. This study consists of a three-group cross-sectional analysis to compare the circulating metabolome of cancer-free Lynch syndrome carriers, sporadic colorectal cancer (CRC) patients, and healthy non-carrier controls. We detected elevated levels of circulating cholesterol, lipids, and lipoproteins in LS carriers. Furthermore, we unveiled that Lynch syndrome carriers and CRC patients displayed similar alterations compared to healthy non-carriers in circulating amino acid and ketone body profiles. Overall, cancer-free Lynch syndrome carriers showed a unique circulating metabolome landscape. This study provides valuable insights into the systemic metabolic landscape of Lynch syndrome individuals. The findings hint at shared metabolic patterns between cancer-free Lynch syndrome carriers and CRC patients.