The deleterious effects of aging on force production are observable from the age of 40 upwards, depending on the measure. Neural mechanisms contributing to maximum force production and rate of force development have been suggested as descending drive from supraspinal centers, spinal motoneuron excitability, and corticospinal inhibition of descending drive; all of which influence motor unit recruitment and/or firing rate. Resistance-trained Master athletes offer a good source of information regarding the inevitable effects of aging despite the countermeasure of systematic resistance-training. However, most evidence of neural adaptation is derived from longitudinal intervention studies in previously untrained (i.e. resistance-training naïve) older adults. There is good evidence for the effect of resistance-training on the end-point of neural activation, i.e. motor unit behavior, but little to no data on the generation of descending drive from e.g. transcranial magnetic stimulation or cortical imaging studies in older adults. This, along with tracking master athletes over several years, would provide valuable information and could be the focus of future research.